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VG1 has been shown as an inhibitor of Nonsense Mediated Decay (NMD) by researchers at the University of Sheffield and is a useful tool for developing an understanding of both the mechanism of NMD and of other related mRNA decay pathways.

Nonsense mediated decay

Nonsense mediated decay (NMD) is an mRNA quality control mechanism in mammals which degrades mRNA sequences that contain premature termination codons (PTC). The resulting low levels of associated protein give rise to the symptoms of PTC-associated diseases. One potential approach to the treatment of diseases caused by PTC mutations is the inhibition of NMD. Therefore there is a need to discover and develop drugs that inhibit NMD selectively.


VG1 is a new tetracyclic compound, originally prepared and tested in the labs of Prof Iain Coldham and Prof Carl Smythe at the University of Sheffield. This compound was found to have good activity as an inhibitor of nonsense-mediated mRNA decay. The compound is a close analogue of known NMD inhibitor NMDI1 and can therefore be used in a toolkit of molecules to study the NMD mechanism.

Available now from Redbrick Molecular

Researchers can now buy VG1 at small scale through Redbrick Molecular’s off the shelf catalogue – simply contact us with a quote request!

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Supporting Documents
DOI: 10.1039/C5OB02482J (Communication)
Org. Biomol. Chem., 2016, 14, 1559-1563